The Anti-Pan-Cadherin antibody (monoclonal) from MyBioSource.com is a Mouse Monoclonal antibody to arc-1, Cadherin E, CD324, CDH1, CDHE, E Cadherin, E-Cadherin, ECAD, FZr, FZR1, and LCAM. This antibody recognizes Human, Mouse, Rat, Chicken/Bird, Reptile, and Rabbit antigen. The Anti-Pan-Cadherin antibody (monoclonal) has been validated for the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Description: Mouse IgG monoclonal antibody for Pan-Cadherin, cadherin 1, type 1, E-cadherin (epithelial), cadherin 2, type 1, N-cadherin (neuronal), cadherin 3, type 1, P-cadherin (placental) (CDH1, CDH2, CDH3) detection. Tested with WB, IHC-P in Human, mouse, rat, rabbit, chicken, snake. No cross reactivity with other proteins. Uniprot ID: P12830
Background: Cadherins are calcium-dependent cell-cell adhesion molecules that mediate cell-cell binding in a homophilic manner. They play an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Cadherin expression is regulated spatially as well as temporally. Cadherins are though to play an important role in development and maintenance of tissues through selective cell-cell adhesion activity and may be involved also in the invasion and metastasis of malignant tumors. Cadherin regulates dendritic spine morphogenesis. A cadherin gene cluster is mapped to a region of chromosome 5 subject to frequent allelic loss in carcinoma